Folic acid can correct the anemia that is caused by vitamin B12 deficiency. Unfortunately, folic acid will not correct the nerve damage also caused by vitamin B12 deficiency. Permanent nerve damage can occur if vitamin B12 deficiency is not treated. Folic acid intake from food and supplements should not exceed 1,000 g daily in healthy individuals because large amounts of folic acid can trigger the damaging effects of vitamin B12 deficiency. Adults older than 50 years who take a folic acid supplement should ask their physician or qualified health care provider about their need for additional vitamin B12.
Cardiovascular illnesses comes to any ailment of cardiovascular system and you may bloodstream that comprise the newest center. Coronary heart condition happens when blood vessels which provide the cardio become clogged or blocked, raising the danger of a stroke. Vascular damage can also happen in order to arteries giving the notice, and can cause a coronary attack.
Cardiovascular illnesses is considered the most prominent reason behind demise within the industrialized countries like the You, which will be on the rise during the development nations. The fresh Federal Cardiovascular system, Lung, and you may Blood Institute of Federal Schools away from Health provides understood many risk things getting heart problems, and additionally an elevated LDL-cholesterol rate, hypertension, the lowest HDL-level of cholesterol, obesity, and you can all forms of diabetes. Nowadays, experts has actually recognized another risk grounds sito incontri Women’s Choice to own cardiovascular disease: a heightened homocysteine level. Homocysteine is a keen amino acid normally found in blood, however, elevated accounts had been linked with cardiovascular condition and you can heart attack. Increased homocysteine profile may hurt endothelial vasomotor setting, which establishes how with ease bloodstream moves courtesy bloodstream. High levels of homocysteine in addition to ages coronary arteries and make they more comfortable for bloodstream clotting structure entitled platelets so you’re able to clump along with her and you can means a clog, which may produce a coronary arrest.
Vitamin B12, folate, and vitamin Bsix are involved in homocysteine metabolism. In fact, a deficiency of vitamin B12, folate, or vitamin B6 may increase blood levels of homocysteine. Recent studies found that vitamin B12 and folic acid supplements decreased homocysteine levels in subjects with vascular disease and in young adult women. The most significant drop in homocysteine level was seen when folic acid was taken alone. A significant decrease in homocysteine levels also occurred in older men and women who took a multivitamin/ multimineral supplement for 8 weeks. The supplement taken provided 100% of Daily Values (DVs) for nutrients in the supplement.
Evidence supports a role for folic acid and vitamin B12 supplements for lowering homocysteine levels, however this does not mean that these supplements will decrease the risk of cardiovascular disease. Clinical intervention trials are underway to determine whether folic acid, vitamin B12, and vitamin B6 supplements can lower risk of coronary heart disease. It is premature to recommend vitamin B12 supplements for the prevention of heart disease until results of ongoing randomized clinical trials positively link increased vitamin B12 intake from supplements with decreased homocysteine levels and decreased risk of cardiovascular disease.
It is generally accepted that older adults are at greater risk of developing a vitamin B12 deficiency than younger adults. One study, however, suggests that the prevalence of vitamin B12 deficiency in young adults may be greater than previously thought. This study found that the percentage of subjects in three age groups (26-49 years, 50-64 years, and 65 years and older) with deficient blood levels of vitamin B12 was similar across all age groups but that symptoms of vitamin B12 deficiency were not as apparent in younger adults. This study also suggested that those who did not take a supplement containing vitamin B12 were twice as likely to be vitamin B12 deficient as supplement users, regardless of age group. However, people who did not use supplements but did eat fortified cereal more than 4 times per week appeared to be protected from deficient blood levels of vitamin B12. Better tools and standards to diagnose vitamin B12 deficiencies are needed to make specific recommendations about the appropriateness of vitamin B12 supplements for younger adults.